HLA Typing in Ethiopia

A genetic test called HLA typing is used to identify unique variations in a person’s immune system. The process is essential for figuring out who may safely give bone marrow, cord blood, or an organ to a patient needing a transplant. Human leukocyte antigen is called HLA, even though that is its full name. HLA typing is also known as HLA matching. The HLA Typing cost in Ethiopia is around $800. Ethiopia has the best labs to provide highly regulated HLA typing test results, and all the procedures are successfully performed in Ethiopia.

What is HLA Typing Test?

Organ and tissue transplant recipients are matched with compatible donors via HLA testing. Different transplants need various degrees of compatibility between donors and recipients.

A way to assess how closely the tissues of a transplant recipient and their potential donor match each other is known as human leukocyte antigen (HLA) typing.

HLA typing is a medical test determining whether blood and bone marrow donors and transplant recipients are adequately and securely matched.

HLA Typing Cost in Ethiopia

Types of HLA Typing Tests

Serotyping:

Antibodies specific to HLA proteins are employed in serotyping, a non-sequencing-based approach of typing, to identify the proteins on the surface of cells.

Specific Oligonucleotide Hybridization (SSO):

Sequence-Specific oligos are first generated for genes of interest and then hybridized to the patient or donor DNA to check for hybridization. This is the Specific Oligonucleotide Hybridization (SSO) HLA Typing technique.

Sanger Sequencing:

High-resolution HLA typing for HLA – A, – B, – C, – DR, – DQ, and – DP locus alleles is provided by Sanger sequencing-based typing, which is necessary for HSC transplantation. Sanger SBT’s limitations include time-consuming methods, low throughput, unphased data, and genotype ambiguity, even though it offers more resolution than SSP or SSOP.

Next-generation SBT:

The gold standard for high-resolution HLA genotyping is quickly emerging as high-resolution SBT by next-generation sequencing (NGS). Higher throughput, the capacity to examine additional HLA gene areas, and decreased genotype ambiguity are all features of NGS technology. The quantity of novel HLA sequences and alleles submitted to HLA databases has greatly increased due to NGS HLA typing.

HLA Typing Cost in Ethiopia – Bone Marrow Transplants

Human leukocyte antigen (HLA) typing is performed for bone marrow transplants to match patients and donors. HLA are proteins or markers present in most of your body’s cells. The match of HLA Typing is necessary for bone marrow transplantation. National Donar Registry is available to find a matched HLA Typing bone marrow. The HLA Typing Test is available in Ethiopian hospitals using the top technologies. The HLA Typing Cost in Ethiopia is around $850 for Bone Marrow Transplant. 

HLA Typing Cost in Ethiopia – Kidney Transplants

Successful procedures that revealed superior graft survival in HLA identical kidney transplants compared to HLA mismatched transplants illustrate the significance of HLA matching in kidney transplantation. The HLA Typing in Ethiopia is used in Kidney Transplants to get the best acceptance rate and successful transplant. The HLA Typing cost in Ethiopia for Kidney transplants is $750.

HLA Typing Cost in Ethiopia – Liver Transplants

The HLA antigens contribute to the etiology of the disease, which may reject if the HLA typing is not matched. A matched HLA Typing is required in liver transplantation. The HLA Typing cost in Ethiopia for Liver transplants is $700.

High-Resolution HLA Typing Cost in Ethiopia

HLA A and B, HLA-DR, and HLA-DQ are used in HLA high-resolution typing, also known as human leukocyte antigens. This process uses the aforementioned antigens for organ transplantation and bone marrow. Tissue typing is the most crucial step in finding antibodies to HLA antigens. If any antibodies are found in the antigens, the cells will bind to them as a result. In other terms, it is usually referred to as histocompatibility testing and is used to identify antigens in White Blood Cells. The High-Resolution HLA Typing Cost in Ethiopia is around $900.

HLA Typing Cost in Ethiopia

HLA Typing Test Details

Why are HLA typing tests required?

Below is a list of conditions for which HLA typing tests were necessary:

• For various organ transplants, including liver, kidney, and heart.
• To match donors with recipients of bone marrow transplants who have sickle cell anemia.
• Lymphoma, Leukemia, Multiple Myeloma, and Hemophilia diagnoses.
• Several immune-mediated and autoimmune diseases, such as juvenile rheumatoid arthritis, reactive arthritis, and ankylosing spondylitis, are associated with the HLA-B27 Test.
• HLA typing is a medical test determining whether blood and bone marrow donors and transplant recipients are adequately and securely matched.

Donor Registries

Confidential online databases where people can register and store their intent to be organ and tissue donors. Many registries offer online registry portals; most accept applications through motor vehicle offices. It is the fastest and safest method to determine whether a deceased person wishes to be a donor or is seeking a donor who is a perfect match because registry information is accessible to authorized procurement experts 24/7.

Several authorized registers operate for social welfare throughout the world; a few are the following:

• German Registry: DKMS
• Indian Registry: DATRI
• An American registry: The National Marrow Donor Program (NMDP) has run the largest various marrow registry in the world under its Be The Match brand.

Importance of HLA Typing

The number of donated organs yearly is increasing used in organ transplants. National and international organizations are crucial in collecting and distributing donor organs and bone marrow for transplant procedures. In addition, they serve as intermediaries between donors and recipients. A centralized computer database contains information on all potential organ recipients, including blood type and tissue characteristics.

The patient is then added to a waiting list. When an organ donor becomes available, the local tissue-typing laboratory establishes the donor’s blood and tissue characteristics. The registration facility where the patient is chosen receives all pertinent information on the donor at that point. A key consideration in this decision is the HLA match. Every donor’s blood and HLA type are kept in a centralized database for bone marrow transplants. There are already more than 8.8 million registered volunteer donors in the world.

Success Rate of HLA Typing in Ethiopia

Successful allogeneic hematopoietic stem cell transplantation depends on HLA matching. The success rate of organ transplant surgery has significantly increased in recent years thanks to technical developments. Increased liver and kidney transplant surgeries should drive the demand for HLA typing. HLA typing tests are highly successful in Ethiopia because of the top-notch technologically advanced labs.

HLA Typing Centers in Ethiopia

Ethiopian labs and centers offer a highly advanced medical laboratory and highly qualified personnel who deliver precise diagnostic findings on various tests with accuracy comparable to labs in other countries. They offer a comprehensive solution for all clinical testing requirements in a practical, high-quality setting that decreases turnaround time and logistics-related expenses.

Insurance Coverage for HLA Typing in Ethiopia

In Ethiopia, no government fund is provided as insurance coverage for HLA Typing. But a few well-known private insurance companies are providing coverage for HLA typing. The insurance coverage helps patients to get a cash-free HLA Typing in Ethiopia, where the patients are economically weak.

FAQs on HLA Typing in Ethiopia